abstract：:Hair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR-124 in the neural differentiation of HFSCs has not been elucidated. HFSCs were isolated from mouse whisker follicl...

journal_title：Journal of cellular physiology

authors： Mokabber H,Najafzadeh N,Mohammadzadeh Vardin M

更新日期：2019-06-01 00:00:00

abstract：:The clonal hematopoiesis when occurring without hematologic abnormalities is defined as clonal hematopoiesis of indeterminate potential (CHIP). Aging causes accumulation of somatic mutations, and hematopoietic stem cells (HSCs) can develop clonal expansion of different lineages by these mutations. CHIP has a correlati...

journal_title：Journal of cellular physiology

authors： Haybar H,Shahrabi S,Ghanavat M,Khodadi E

更新日期：2019-06-01 00:00:00

abstract：:Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer-associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma...

journal_title：Journal of cellular physiology

authors： Pan B,Zhao M,Xu L

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:In this study, we aimed to explore the effects of GAS5 single-nucleotide polymorphisms (SNPs) on GAS5 expression. And the signaling pathways underlying the function of GAS5 during the pathogenesis of prostate cancer (PC) were clarified. MATERIALS AND METHODS:Patients with PC were recruited and grouped accor...

journal_title：Journal of cellular physiology

authors： Zhu L,Zhu Q,Wen H,Huang X,Zheng G

更新日期：2019-06-01 00:00:00

abstract：:We report here that the androgen receptor (AR) and ABCB1 are upregulated in a model of acquired taxol resistance (txr) in ovarian carcinoma cells. AR silencing sensitizes txr cells to taxol threefold, whereas ectopic AR expression in AR-null HEK293 cells induces resistance to taxol by 1.7-fold. AR activation using the...

journal_title：Journal of cellular physiology

authors： Sun NK,Kohli A,Huang SL,Chang TC,Chao CC

更新日期：2019-06-01 00:00:00

abstract：:Resistin, secreted by macrophages in tumor microenvironment, has never been investigated in pancreatic cancer models, despite a vibrant tumor microenvironment around pancreatic tumors. We evaluated serum resistin levels in healthy individuals versus pancreatic cancer patients representing different tumor grades. In vi...

journal_title：Journal of cellular physiology

authors： Zhang M,Yan L,Wang GJ,Jin R

更新日期：2019-06-01 00:00:00

abstract：:Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin-13/APJ confers a proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed to investig...

journal_title：Journal of cellular physiology

authors： He L,Zhou Q,Huang Z,Xu J,Zhou H,Lv D,Lu L,Huang S,Tang M,Zhong J,Chen JX,Luo X,Li L,Chen L

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is characterized by the apoptosis resistance and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Its pathogenesis has not been revealed. Here, we carried out experiments to investigate the functions of miR-140-5p and tumor necrosis factor-α (TNF-α). ...

journal_title：Journal of cellular physiology

authors： Zhu TT,Zhang WF,Yin YL,Liu YH,Song P,Xu J,Zhang MX,Li P

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Disc degeneration is the common life-threatening disease characterized by flank pain. The gene expression of insulin-like growth factor binding protein 3 (IGFBP3) is increased in patients with disc degeneration, however, its mechanism is still unknown. This study aimed to investigate the influence of IGFBP3 g...

journal_title：Journal of cellular physiology

authors： Chen G,Zhou X,Xu Z

更新日期：2019-06-01 00:00:00

abstract：:Sprouting angiogenesis is a major form of neovascularization of tissues suffering from hypoxia and other related stress. Endothelial cells (ECs) undergo proliferation, differentiation, programmed death, and migration during angiogenic sprouting, but the underlying molecular mechanisms regulating ECs in angiogenesis ha...

journal_title：Journal of cellular physiology

authors： Liu Y,Zheng Q,He G,Zhang M,Yan X,Yang Z,Zhang P,Wang L,Liu J,Liang L,Han H

更新日期：2019-06-01 00:00:00

abstract：:ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame-shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snai...

journal_title：Journal of cellular physiology

authors： Zhu D,Zhou J,Zhao J,Jiang G,Zhang X,Zhang Y,Dong M

更新日期：2019-06-01 00:00:00

abstract：:Characteristic features like self-renewal, multilineage differentiation potential, and immune-modulatory/anti-inflammatory properties, besides the ability to mobilize and home distant tissues make stem cells (SCs) a lifeline for an individual. Stem cells (SCs) if could be harvested and expanded without any abnormal ch...

journal_title：Journal of cellular physiology

authors： Gugjoo MB,Amarpal,Fazili MR,Shah RA,Sharma GT

更新日期：2019-06-01 00:00:00

abstract：:Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells fo...

journal_title：Journal of cellular physiology

authors： Hassanshahi A,Hassanshahi M,Khabbazi S,Hosseini-Khah Z,Peymanfar Y,Ghalamkari S,Su YW,Xian CJ

更新日期：2019-06-01 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. IBS could seriously affect lifetime of patients and cause high economic burden on the community. The pathophysiology of the IBS is hardly understood, whereas several possible me...

journal_title：Journal of cellular physiology

authors： Shariati A,Fallah F,Pormohammad A,Taghipour A,Safari H,Chirani AS,Sabour S,Alizadeh-Sani M,Azimi T

更新日期：2019-06-01 00:00:00

abstract：:Plasminogen activator inhibitor-1 (PAI-1) is known as an inhibitor of fibrinolytic system. Previous studies suggest that PAI-1 is involved in the pathogenesis of osteoporosis induced by ovariectomy, diabetes, and glucocorticoid excess in mice. However, the roles of PAI-1 in early-stage osteogenic differentiation have ...

journal_title：Journal of cellular physiology

authors： Takafuji Y,Tatsumi K,Ishida M,Kawao N,Okada K,Matsuo O,Kaji H

更新日期：2019-06-01 00:00:00

abstract：:Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified, the epigenetic mechanisms that sustain this expression in differentiated osteoblasts remain to be completely determin...

journal_title：Journal of cellular physiology

authors： Rojas A,Sepulveda H,Henriquez B,Aguilar R,Opazo T,Nardocci G,Bustos F,Lian JB,Stein JL,Stein GS,van Zundert B,van Wijnen AJ,Allende ML,Montecino M

更新日期：2019-05-01 00:00:00

abstract：:Cancer is one of the common lifestyle diseases and is considered to be the leading cause of death worldwide. Epstein-Barr virus (EBV)-infected individuals remain asymptomatic; but under certain stress conditions, EBV may lead to the development of cancers such as Burkitt's and Hodgkin's lymphoma and nasopharyngeal car...

journal_title：Journal of cellular physiology

authors： Ojha R,Nandani R,Prajapati VK

更新日期：2019-05-01 00:00:00

abstract：:Spiral artery remodeling at the maternal-fetal interface is crucial for successful pregnancy and requires the interaction between the first trimester trophoblast and the endothelial cells of the maternal vessels. However, the precise mechanism of this dialog has yet to be determined. The current study investigated whe...

journal_title：Journal of cellular physiology

authors： Beltrame JS,Scotti L,Sordelli MS,Cañumil VA,Franchi AM,Parborell F,Ribeiro ML

更新日期：2019-05-01 00:00:00

abstract：:Cardiac fibroblast (CF) differentiation to myofibroblasts expressing α-smooth muscle actin (α-SMA) plays a key role in cardiac fibrosis. Therefore, a study of the mechanism regulating α-SMA expression is a means to understanding the mechanism of fibroblast differentiation and cardiac fibrosis. Previous studies have sh...

journal_title：Journal of cellular physiology

authors： He Y,Ling S,Sun Y,Sheng Z,Chen Z,Pan X,Ma G

更新日期：2019-05-01 00:00:00

abstract：:Excess reactive oxygen species (ROS) generated in embryos during in vitro culture damage cellular macromolecules and embryo development. Glutathione (GSH) scavenges ROS and optimizes the culture system. However, how exogenous GSH influences intracellular GSH and improves the embryo developmental rate is poorly underst...

journal_title：Journal of cellular physiology

authors： Li F,Cui L,Yu D,Hao H,Liu Y,Zhao X,Pang Y,Zhu H,Du W

更新日期：2019-05-01 00:00:00

abstract：:Although immortalized cultured cells are useful for various functional assays or transcriptome analysis, highly efficient and reproducible immortalization methods have not been developed in avian-derived cells. We introduced the simian virus 40 T antigen (SV40T) and human papillomavirus (HPV)-E6E7 to chick and Okinawa...

journal_title：Journal of cellular physiology

authors： Katayama M,Kiyono T,Ohmaki H,Eitsuka T,Endoh D,Inoue-Murayama M,Nakajima N,Onuma M,Fukuda T

更新日期：2019-05-01 00:00:00

abstract：:Skeletal muscle atrophy/wasting is associated with impaired protein metabolism in diverse physiological and pathophysiological conditions. Elevated levels of reactive oxygen species (ROS), disturbed redox status, and weakened antioxidant defense system are the major contributing factors toward atrophy. Regulation of p...

journal_title：Journal of cellular physiology

authors： Kaur N,Gupta P,Saini V,Sherawat S,Gupta S,Dua A,Kumar V,Injeti E,Mittal A

更新日期：2019-05-01 00:00:00

abstract：:Obesity predisposes to glucose intolerance and type 2 diabetes (T2D). This disease is often characterized by insulin resistance, changes in insulin clearance, and β-cell dysfunction. However, studies indicate that, for T2D development, disruptions in glucagon physiology also occur. Herein, we investigated the involvem...

journal_title：Journal of cellular physiology

authors： Araujo TR,da Silva JA,Vettorazzi JF,Freitas IN,Lubaczeuski C,Magalhães EA,Silva JN,Ribeiro ES,Boschero AC,Carneiro EM,Bonfleur ML,Ribeiro RA

更新日期：2019-05-01 00:00:00

abstract：:Increasing evidence has demonstrated that abnormal expression of lncRNA is correlated with various malignant tumors, including hepatocellular carcinoma (HCC). Our current study was aimed to investigate the role of LINC00707 in HCC development. We observed that LINC00707 was upregulated in HCC cell lines compared with ...

journal_title：Journal of cellular physiology

authors： Wang J,Luo Z,Yao T,Li W,Pu J

更新日期：2019-05-01 00:00:00

abstract：:Neuropathic pain caused by somatosensory nervous system dysfunction is a serious public health problem. Some long noncoding RNAs (lncRNAs) can participate in physiological processes involved in neuropathic pain. However, the effects of lncRNA DGCR5 in neuropathic pain have not been explored. Therefore, in our current ...

journal_title：Journal of cellular physiology

authors： Peng C,Zhang C,Su Z,Lin D

更新日期：2019-05-01 00:00:00

abstract：:1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one (EB30) is a diarylheptanoid-like compound isolated from Viscum coloratum. This curcumin analog exhibits significant cytotoxic activity against HeLa, SGC-7901, and MCF-7 cells. However, little is known about the anticancer effects and mechanisms of EB30 in human lung cancer....

journal_title：Journal of cellular physiology

authors： Fan J,Wu M,Wang J,Ren D,Zhao J,Yang G

更新日期：2019-05-01 00:00:00

abstract：:Endometriosis is a chronic gynecological inflammatory disorder in which immune system dysregulation is thought to play a role in its initiation and progression. Due to altered sex steroid receptor concentrations and other signaling defects, eutopic endometriotic tissues have an attenuated response to progesterone. Thi...

journal_title：Journal of cellular physiology

authors： Chowdhury I,Banerjee S,Driss A,Xu W,Mehrabi S,Nezhat C,Sidell N,Taylor RN,Thompson WE

更新日期：2019-05-01 00:00:00

abstract：:Osteogenic differentiation is a complicated process that depends on various regulatory factors and signal pathways. In our research, the osteogenic differentiation capacity was analyzed by alizarin red staining, alkaline phosphatase activity, and protein levels of osteogenic differentiation markers including runt-rela...

journal_title：Journal of cellular physiology

authors： Li Z,Sun Y,Cao S,Zhang J,Wei J

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of polo-like kinase 1 (PLK1) inhibition on cisplatin (DDP)-resistant gastric cancer (GC) cells. METHODS:The transcriptional level of PLK1 was measured by quantitative reverse-transcription polymerase chain reaction. Expressions of PLK1 and its downstream mediators as...

journal_title：Journal of cellular physiology

authors： Chen Z,Chai Y,Zhao T,Li P,Zhao L,He F,Lang Y,Qin J,Ju H

更新日期：2019-05-01 00:00:00

abstract：:We have previously shown that knockout of fibroblast growth factor-2 (FGF-2) and potential compensatory effects of other growth factors result in amelioration of disease symptoms in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). ALS is a rapidly progressive neurological disorder leading to degenerati...

journal_title：Journal of cellular physiology

authors： Kefalakes E,Böselt S,Sarikidi A,Ettcheto M,Bursch F,Naujock M,Stanslowsky N,Schmuck M,Barenys M,Wegner F,Grothe C,Petri S

更新日期：2019-05-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory respo...

journal_title：Journal of cellular physiology

authors： Fujihara C,Kanai Y,Masumoto R,Kitagaki J,Matsumoto M,Yamada S,Kajikawa T,Murakami S

更新日期：2019-05-01 00:00:00

abstract：:Multiple studies have reported different methods in treating gestational diabetes mellitus (GDM); however, the relationship between miR-335-5p and GDM still remains unclear. Here, this study explores the effect of miR-335-5p on insulin resistance and pancreatic islet β-cell secretion via activation of the TGFβ signali...

journal_title：Journal of cellular physiology

authors： Tang XW,Qin QX

更新日期：2019-05-01 00:00:00

abstract：:Growing evidence from recent studies has shown that the X-inactive specific transcript (XIST), a well-known long noncoding RNA involved in early embryonic development, is aberrantly regulated in various human cancers. However, the prognostic value of XIST in cancers remains uncharacterized. In this study, we searched ...

journal_title：Journal of cellular physiology

authors： Liu JL,Zhang WQ,Zhao M,Huang MY

更新日期：2019-05-01 00:00:00

abstract：:Neuropathic pain (NP) may cause serious brain diseases, but the genes associated with the metabolic pathway and transcript factors of NP remain unclear. This study is aimed to identify the therapy target genes for NP and to investigate the metabolic pathways and transcript factors associated with NP. The differentiall...

journal_title：Journal of cellular physiology

authors： Yan XT,Xu Y,Cheng XL,He XH,Wang Y,Zheng WZ,Zhao Y,Chen H,Wang YL

更新日期：2019-05-01 00:00:00

abstract：:Patent ductus arteriosus is the third most common congenital heart disease and resulted from the persistence of ductal patency after birth. Ductus arteriosus closure involves functional and structural remodeling, controlled by many factors. The changes in plasma protein levels associated with PDA closure are not known...

journal_title：Journal of cellular physiology

authors： Hou HT,Xi-Zhang,Wang J,Liu LX,Zhang JF,Yang Q,He GW

更新日期：2019-05-01 00:00:00

abstract：:Cementum, which shares common features with bone in terms of biochemical composition, is important for the homeostasis of periodontium during periodontitis and orthodontic treatment. Sirtuin 6 (SIRT6), as a member of the sirtuin family, plays key roles in the osteogenic differentiation of bone marrow mesenchymal stem ...

journal_title：Journal of cellular physiology

authors： Huang L,Sun H,Song F,Cao Z,Jiang X,Zhang L,Li Z,Huang C

更新日期：2019-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proli...

journal_title：Journal of cellular physiology

authors： Chen Y,Zhao ZX,Huang F,Yuan XW,Deng L,Tang D

更新日期：2019-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the lethal and difficult-to-cure cancers worldwide. Owing to the late diagnosis and drug resistance of malignant hepatocytes, treatment of this cancer by conventional chemotherapy agents is challenging, and researchers are seeking new alternative treatment options to overcome t...

journal_title：Journal of cellular physiology

authors： Hajiasgharzadeh K,Somi MH,Shanehbandi D,Mokhtarzadeh A,Baradaran B

更新日期：2019-04-01 00:00:00

abstract：:Recent data indicate that the Simian virus 40 (SV40) infection appears to be transmitted in humans independently from early SV40-contaminated antipolio vaccines. Serum antibodies against SV40 large T antigen (Tag) were analyzed in children/adolescents and young adults. To investigate antibodies reacting to SV40 Tag an...

journal_title：Journal of cellular physiology

authors： Mazzoni E,Frontini F,Rotondo JC,Zanotta N,Fioravanti A,Minelli F,Torreggiani E,Campisciano G,Marcuzzi A,Guerra G,Tommasini A,Touzé A,Martini F,Tognon M,Comar M

更新日期：2019-04-01 00:00:00

abstract：:Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory disorder, is caused by a dysregulated and aberrant immune response to exposed environmental factors in genetically susceptible individuals. Despite huge efforts in determining the molecular pathogenesis of IBD, an increasing worldwide incidence ...

journal_title：Journal of cellular physiology

authors： Moein S,Vaghari-Tabari M,Qujeq D,Majidinia M,Nabavi SM,Yousefi B

更新日期：2019-04-01 00:00:00